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Elucidating the role of matrix stiffness

elucidating the role of matrix stiffness-33

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Our results also suggest that co-overexpression of the 14-3-3ζ and Erb B2 proteins facilitates cell migratory capacity in 3D matrices, as reflected in cell migration speed.To this end, we use time-lapsed confocal microscopy to investigate the interplay among cell motility, three-dimensional (3D) matrix stiffness, matrix architecture, and transforming potential in a mammary epithelial cell (MEC) cancer progression series.We use a well characterized breast cancer progression model where human-derived MCF10A MECs overexpress either Erb B2, 14-3-3ζ, or both Erb B2 and 14-3-3ζ, with empty vector as a control.(2013) Generating simulators from multi-level coordinated specifications Wang, Guanbo (2013) Tools for probing protein higher-order structure: Monitoring aggregation with native ESI-MS and conformational dynamics with top-down h/d exchange MS Wang, Meng (2013) Investigation of microalgae cultivation and anaerobic codigestion of algae and sewage sludge for wastewater treatment facilities Wang, Shunhai (2013) Development of mass spectrometry-based methods for quantitation and characterization of protein drugs: transferrin as a model drug delivery vehicle Wang, Yanbo (2013) Computer simulations of polyelectrolyte stretching and translocation Wanwong, Sompit (2013) Molecular designs for charge and ion transporting materials White, Ted (2013) Seeds of a new economy?A qualitative investigation of diverse economic practices within community supported agriculture and community supported enterprise Wiehe, Elsa M (2013) Racialized spaces in teacher discourse: A critical discourse analysis of place-based identities in Roche Bois, Mauritius Williams, Pamela Lagergren (2013) A multidirectional Memory Approach to Representations of Colonization, Racism, and Genocide in Literature Xiao, Sheng (2013) Dynamic secrets in communication security Yang-Handy, Angela Kathryn (2013) Preparing visually-impaired people in the Philippines for mainstream employment: Perceptions of the impact of ICT accessibility Yang, Jin (2013) Experimental and computational studies of aqueous-phase hydrogenation of biorenewable aromatic chemicals Yao, Li (2013) Self-assembly of block copolymers for the fabrication of functional nanomaterials Yetis Bayraktar, Ayse (2013) Parents' socioeconomic class position and children's time use patterns Yoon, Ilsang (2013) Bayesian anatomy of galaxy structure Yucesoy, Burcu (2013) Replica exchange Monte Carlo simulations of the ising spin glass: Static and dynamic properties Yu, Xi (2013) Assembly of surface engineered nanoparticles for functional materials Yu, Xunyi (2013) Hybrid radio frequency and video framework for identity-aware augmented perception in disaster management and assistive technologies Zajac, Timothy W (2013) The everyday feast: Recreational consumption and social status in early modern English drama Zdybel, Rose M (2013) R&D portfolio analysis of low carbon energy technologies to reduce climate change mitigation costs Zencirci, F.The equity exchange theory of marketing Ruane, Sinead G (2013) Coaching the self: Identity work(ing) and the self-employed professional Ryan, Kelly C (2013) Investigation of the structure/function relationship in nickel containing superoxide dismutase Samanta, Satamita (2013) Hybrid push: A mechanistic model for initial transcription common to all RNA polymerases Sarkar, Sreela (2013) Technology and modernity at the boundaries of global Delhi Schneebaum, Alyssa (2013) The economics of same-sex couple households: Essays on work, wages, and poverty Schulze, Joshua (2013) Supporting the persuasive writing practices of English language learners through culturally responsive systemic functional linguistic pedagogy Schupack, Sara (2013) Circle and lines: Complexities of learning in community Seda-Irizarry, Ian J (2013) The political economy of cultural production: Essays on music and class Sehgal, Ray Mohan (2013) Coarse-Grained Modeling of the Phase Behavior of Thermodynamically Small Particle Assemblies Sen, Shiraj (2013) Bridging the gap between autonomous skill learning and task-specific planning Sharma, Navin Kumar (2013) Designing distributed systems for intermittent power Sharma, Upendra (2013) Elastic resource management in cloud computing platforms Shea, Christine A (2013) Using a mixture IRT model to understand English learner performance on large-scale assessments Shen, Erica Yibei (2013) Effects of chronic administration of THC on MDMA-induced physiological, behavioral, and neurochemical alterations Sherpa, Mingma Norbu (2013) Conservation governance and management of Sagarmatha (Mt. Titus, Janel (2013) Regulation of Eg5 and TPX2 during mammalian mitosis Torner, Evan (2013) The race-time continuum: Race projection in DEFA genre cinema Trabal-Del Valle, Jorge M (2013) Data quality assessment and rainfall estimation using dense radar networks Tran, Thanh T.

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We conclude that 3D microenvironmental signals act synergistically with reprogramming transcription factors to increase somatic plasticity.