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It is only when the weight of infection has increased and the profitability has suffered or when antibiotic resistance has become complete, especially in the case of swine dysentery, that they will consider complete depopulation and repopulation.This is an opportunity to restock with high-health herds, free of many of the above diseases.

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Enzootic pneumonia () and porcine reproductive and respiratory syndrome virus (PRRSV) are typical examples of such diseases.Once the breeding herd is free, then only PRRSV-free gilts can be introduced. The success rate is quite low due to failures normally in biosecurity.In the US, they see a 40 per cent breakdown of herds per year (Morrison & Torremorell, 2014).The use of newer long-acting formulations of compounds such as marbofloxacin and tulathromycin by injection may increase the rate of success and these need to be looked at further.This disease is an on-going problem in many herds and successful eradication is rarely reported (Strachan, et al, 2003).The following sections look at opportunities to improve the success rate of eradication programmes, to improve their risk/benefit and thereby improve the health and productivity of pig herds.

On its own, enzootic pneumonia is generally mild in a herd.

Repopulation with high-health stock does have its own issues, such as cost, associated with purchasing high-health stock, cleaning and disinfecting the farm and loss of production for six or eight months.

Other factors also include herd biosecurity and the risk of breaking down with endemic diseases in the future, especially in pig dense regions.

If this infection is coupled with other diseases such as the immune suppressing PRRSV and potentially acute infection, the level of respiratory disease in the finishing pigs becomes overwhelming and difficult to control, without the extensive use of antibiotics.

The circulation of swine influenza viruses may also add to this disease complex and increase the incidence of pneumonia and pleurisy.

Protocols for eradicating the EU strain have been developed.